Interesting studies Relevant to Chiropractic
Some of the studies that are of interest and relevance to chiropractic care are not actually the
work of chiropractors. Some of these are found in the "medical" literature, osteopathy,
neurology, immunology etc. The studies are brought to your attention only and is by no means
the only bits that maybe should be of interest to chiropractic patients.

This page shall be updated as the information comes to hand. The studies are not placed in
any particular order. Just because it appears first in the list does not mean that the ones listed
lower are of less importance.

Surrogate Indication of DNA Repair in Serum After Long Term
Chiropractic Intervention – A Retrospective Study
Clayton J. Campbell, Christopher Kent, Arthur Banne, Amir Amiri, and Ronald W. Pero;
JVSR, February 18, 2005, pp 1-5

Objective: To assess the effects of short-term and long-term chiropractic care on serum thiol
levels in asymptomatic subjects.

Summary of background data: Serum thiols are a measure of human health status. It is a
surrogate estimate of DNA repair enzyme activity, most notably poly ADP – ribose polymerase
or PARP. While it is suggested that chiropractic care improves general health, the effect of
chiropractic care on serum thiol levels has not been investigated.

Methods: A case controlled retrospective analysis. Serum thiol levels in patients with active
disease (N=46) were compared with serum thiol levels in primary wellness subjects with 8-52
weeks of chiropractic care (N=21) and those who had been under chiropractic care for 52-312
weeks (N=25). Patients were age matched to be 40 years of age or older.

Results: There were statistically significant differences in the serum thiol levels of the three
groups. Mean serum thiol levels were lowest in patients with active disease as well as patients
with initial musculoskeletal complaints. Asymptomatic subjects under chiropractic care
demonstrated higher mean serum thiol levels than patients with active disease. Mean serum
thiol levels were highest in the group with 52-312 weeks of chiropractic care.

Conclusion: Asymptomatic or primary wellness subjects under chiropractic care demonstrated
higher mean serum thiol levels than patients with active disease and produced some values
that were higher than normal wellness values.

Keywords: chiropractic, wellness, adjustment, thiol, DNA repair, oxidative stress

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Resolution of Ataxia in a Pediatric Patient Undergoing

Subluxation-Based Chiropractic Care: A Case Study

Nicoleta Borcean, D.C.

Journal of Pediatric, Maternal & Family Health - Chiropractic Volume: 2009 | Issue: 1 Cover date: 

Winter 2009 Page(s): 1-4


Objective: To report on the response of a pediatric patient with cerebellar ataxia undergoing

chiropractic care.


Clinical Features: A seven-year-old female presented for chiropractic care and cerebellar ataxia

was noted. A thorough examination was performed and isolated the location of trans-neuronal dysfunction

to the right cerebellum.


Interventions and Outcomes: Chiropractic analysis of static and motion palpation were used to

examine the spine for subluxations. High velocity-low amplitude chiropractic adjustments were delivered

to the area of subluxation in either the cervical, thoracic, lumbar and/or pelvic region as needed.

Neuro-rehabilitative exercises were given either at home and/or during the office visit. Within four visits

there was marked improvement of gait patterns and resolution of the ataxia.


Conclusion: Understanding and applying foundational neurological principles via a patient specific,

individually tailored, chiropractic management plan is essential. Assessing and optimizing asymmetrical

neurological indicators should be part of screening and management procedures. In this case, addressing

the dysfunction concerning the central integrative state of the cerebellum was necessary for optimum

functioning of this seven-year-old female.

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Case Study
Reduction of Vertebral Subluxation using Torque Release Technique with Changes in
Fertility: Two Case Reports
Elizabeth Anderson-Peacock, DC, DICCP
JVSR, July 19, 2003, pp 1-6

Objective: This article offers a description of two women who presented with varying
complaints to a family-based chiropractic practice. In each case one of the complaints was

Clinical Features: In both case histories, the women had been deemed medically infertile and
artificial insemination was being considered. Upon presentation, complete chiropractic
evaluations were performed which detected spinal subluxations.

Chiropractic Care and Outcome: Torque Release Technique Protocols were utilized for both
evaluation and application of care. Adjustments were performed with an instrument, the
Integrator, to improve spinal-neural integrity. During the course of chiropractic care both
women were able to conceive.

Conclusion: Although chiropractic care is not a treatment for infertility, it is postulated that
improvement of spinal neural integrity through specific chiropractic adjustments may have
contributed to improved homeostasis and physiological adaptation thus allowing the body to
express a greater level of health as an outcome. Various effects via the reduction of the
vertebral subluxation complex are postulated.

Key words: Chiropractic, Infertility, Torque Release technique, Vertebral Subluxation
Other articles related to infertility:

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Original Research
Eighty-One Patients with Multiple Sclerosis and Parkinson’s Disease Undergoing
Upper Cervical Chiropractic Care to Correct Vertebral Subluxation: A Retrospective
Erin L. Elster, D.C.  
JVSR, August 2, 2004, pp 1-9

Objective: The objective of this article is threefold: to examine the role of head and neck
trauma as a contributing factor to the onset of Multiple Sclerosis (MS) and Parkinson’s disease
(PD); to explore the diagnosis and treatment of trauma-induced injury to the upper cervical
spine through the use of protocol developed by the International Upper Cervical Chiropractic
Association (IUCCA); and to investigate the potential for improving and arresting MS and PD
through the correction of traumainduced upper cervical injury. Data from 81 MS and PD
patients who recalled prior trauma, presented with upper cervical injuries, and received care
according to the above protocol are

Clinical Features: Each patient was examined and cared for in the author’s private practice in
an uncontrolled, non-randomized environment over a five-year period. Of the 81 MS and PD
patients, 78 recalled that they had experienced at least one head or neck trauma prior to the
onset of the disease. In order of frequency, patients reported that they were involved in auto
accidents (39 patients); sporting accidents, such as skiing, horseback riding, cycling, and
football (29 patients); or falls on icy sidewalks or down stairs (16 patients). The duration
between the traumatic event and disease onset varied from two months to 30 years.

Intervention and Outcome: Two diagnostic tests, paraspinal digital infrared imaging and
laser-aligned radiography, were performed according to IUCCA protocol. These tests
objectively identify trauma-induced upper cervical subluxations (misalignment of the upper
cervical spine from the neural canal) and resulting neuropathophysiology. Upper cervical
subluxations were found in all 81 cases. After administering treatment to correct their upper
cervical injuries, 40 of 44 (91%) MS cases and 34 of 37 (92%) PD cases showed symptomatic
improvement and no further disease progression during the care period.

Conclusion: A causal link between trauma-induced upper cervical injury and disease onset for
both MS and PD appears to exist. Correcting the injury to the upper cervical spine through the
use of IUCCA protocol may arrest and reverse the progression of both MS and PD. Further
study in a controlled, experimental environment with a larger sample size is recommended.

Key Indexing Terms: upper cervical spine, chiropractic, Parkinson’s disease, Multiple
Sclerosis, trauma

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Review of the Literature
Objective Physiologic Changes and Associated Health Benefits of Chiropractic
Adjustments in Asymptomatic Subjects: A Review of the Literature
Sean M. Hannon, BA, DC
JVST; April 26, 2004, pp 1-9

Objective: To review existing literature documenting objectively measured physiologic
changes and their associated health benefits subsequent to chiropractic adjustments, primarily
in asymptomatic individuals.

Data Collection: “Asymptomatic” “normal” “pain-free” and “healthy” subjects were keywords
used to search for articles pertaining to the objective. Data was collected directly from the
bound journals of the Palmer College of Chiropractic library in Davenport, IA, Life University
library in Marietta, GA, and the Sherman College of Chiropractic library in Spartanburg, SC.
Some articles were downloaded from peer-reviewed journals accessible through campus
Internet subscription.

Results: More than twenty studies were found documenting objective health benefits in
subjects who were specifically described as “asymptomatic,” “healthy,” “normal,” or “free from
physical injury.” Nearly an equal number of studies were found documenting objectively
measured health benefits in subjects to which no symptomatic presentation was described.

Conclusion: The data reviewed lend support to the contention that chiropractic adjustments,
often for the purpose of correcting vertebral subluxation, confer measurable health benefits to
people regardless of the presence or absence of symptoms. A significant amount of preliminary
evidence supports that people without symptoms can benefit from chiropractic care. Improved
function can be objectively measured in asymptomatic individuals following chiropractic care in
a number of body systems often by relatively non-invasive means. It is plausible that
chiropractic care may be of benefit to every function of the body and have the potential for long-
term, overall health benefit to those receiving chiropractic care.

Key words: chiropractic adjustment, subluxation, objective measurement, health benefit

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Original Research
Atlas Vertebra Realignment and Achievement of Arterial Pressure Goal in
Hypertensive Patients: A Pilot Study
George L. Bakris, M.D, Marshall Dickholtz Sr. D.C., Peter Meyer, Ph.D, Glenda Kravitz, M.S
Elizabeth Avery, MS, Martha Miller BA, Jonathan Brown, D.C, C. Woodfield , Joseph Bruce M.
Bell, M.D, Jason Haas.
JVSRT October 29, 2007 pp 1-9

Anatomical abnormalities of the cervical spine at the level of the Atlas vertebra are associated
with relative ischemia of the brainstem circulation and increased blood pressure (BP). Manual
correction of this mal-alignment has been associated with reduced arterial pressure. This pilot
study tests the hypothesis that correcting mal-alignment of the Atlas vertebra reduces and
maintains lowering BP. Fifty drug na´ve (n=26) or washed out (n=24) subjects with Stage 1
hypertension were evaluated using a randomized, double blind, placebo-controlled study
design at a single center.

Subjects received no antihypertensive meds during the eight-week study duration. After
baseline measures subjects were randomized to receive a National Upper Cervical Chiropractic
(NUCCA) procedure or a sham procedure. Statistical analysis was performed comparing
baseline and week 8 visits. The study was designed with 90% power to detect an 8/5 mmHg
reduction difference in arterial pressure at eight weeks over the placebo group. The study
cohort consisted of 70% males, 2% Hispanic, mean age 52.7+9.6 years. There were no major
differences in baseline demographics found between the two treatment groups.

The primary results of the study are noted in the Table. No adverse effects were recorded. We
conclude that restoration of Atlas alignment is associated with marked reductions in blood
pressure similar to the use of two-drug combination therapy. Larger studies are needed to
validate these findings.

Key Words: atlas; vertebra; antihypertensive therapy

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Reflex effects of subluxation: the autonomic nervous system.
Budgell BS. RMIT University-Japan, Tokyo.
J Manipulative Physiol Ther. 2000 Feb;23(2):104-6.

BACKGROUND: The collective experience of the chiropractic profession is that aberrant
stimulation at a particular level of the spine may elicit a segmentally organized response, which
may manifest itself in dysfunction within organs receiving autonomic innervation at that level.
This experience is at odds with classic views of neuroscientists about the potential for somatic
stimulation of spinal structures to affect visceral function.
OBJECTIVE: To review recent findings from basic physiologic research about the effects of
somatic stimulation of spinal structures on autonomic nervous system activity and the function
of dependent organs.
DATA SOURCE: Findings were drawn from a major recent review of the literature on the
influences of somatic stimulation on autonomic function and from recent original physiologic
studies concerning somatoautonomic and spinovisceral reflexes.
CONCLUSIONS: Recent neuroscience research supports a neurophysiologic rationale for the
concept that aberrant stimulation of spinal or paraspinal structures may lead to segmentally
organized reflex responses of the autonomic nervous system, which in turn may alter visceral

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Improved A1 C Levels in a Patient with Insulin-Dependent Type I Diabetes

Undergoing Chiropractic Care:  A Case Report

Nick Sudano D.C. Bio & Dana Robinson-LeBlanc D.C. Bio

Journal of Pediatric, Maternal & Family Health - Chiropractic ~ Volume 2011 ~ Issue 4 ~ Pages 120-124


Objective:  To describe successful chiropractic care of a patient with Type I Diabetes.

Clinical Features:  A 4-year-old female with Insulin-Dependent Type I Diabetes presented for a chiropractic

evaluation.  Initial examination revealed postural deviations and vertebral subluxations in the cervical, thoracic,

and pelvic regions.

Intervention and Outcomes:  The patient was seen a total of 24 visits.  Gonstead technique protocol was

followed to administer adjustments to reduce vertebral subluxations. There was a significant decrease in

hemoglobin A1C levels which resulted in a lessening of insulin administration.

Conclusion:  The chiropractic care of a pediatric patient with Insulin-Dependent Type I Diabetes is presented. 

More research is warranted on chiropractic care and diabetes.

Key Terms:  chiropractic, Type I diabetes, diabetes mellitus, subluxation, insulin

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Links this page

DNA repair

Cerebellar ataxia
Multiple sclerosis
Parkinson's disease
Adjustment of
asymptomatic patients

Autonomic influence
Type 1 diabetes
Health - Naturally
Mornington & Beechworth, Victoria, Australia


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